An intact PDZ motif is essential for correct P2Y(12) purinoceptor traffic in human platelets

The platelet P2Y(12) purinoceptor (P2Y(12)R), which plays a crucial role in hemostasis, undergoes internalization and subsequent recycling to maintain receptor responsiveness, processes that are essential for normal platelet function. Here, we observe that P2Y(12)R function is compromised after dele...

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Autores principales: Nisar, Shaista, Daly, Martina E., Federici, Augusto B., Artoni, Andrea, Mumford, Andrew D., Watson, Stephen P., Mundell, Stuart J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217363/
https://ncbi.nlm.nih.gov/pubmed/21937696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-336826
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