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Positive feedback between PGE(2) and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells
Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. In the present study, we report that the establishment of a positive feedback loop between prostaglandin E(2) (PGE(2)) and cyclooxygenase 2 (COX2), the key regulator of PGE(2) synthesis, repr...
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| Główni autorzy: | , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217352/ https://ncbi.nlm.nih.gov/pubmed/21972293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-365825 |
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