Positive feedback between PGE(2) and COX2 redirects the differentiation of human dendritic cells toward stable myeloid-derived suppressor cells

Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. In the present study, we report that the establishment of a positive feedback loop between prostaglandin E(2) (PGE(2)) and cyclooxygenase 2 (COX2), the key regulator of PGE(2) synthesis, repr...

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Detaylı Bibliyografya
Asıl Yazarlar: Obermajer, Nataša, Muthuswamy, Ravikumar, Lesnock, Jamie, Edwards, Robert P., Kalinski, Pawel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Immunobiology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217352/
https://ncbi.nlm.nih.gov/pubmed/21972293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-365825
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