PGE(2) transiently enhances DC expression of CCR7 but inhibits the ability of DCs to produce CCL19 and attract naive T cells

Prostaglandin E(2) (PGE(2)) is an inflammatory mediator often used to increase CCR7 expression in the dendritic cells (DCs) used as cancer vaccines and to enhance their responsiveness to lymph node–associated chemokines. Here, we show that high surface expression of CCR7 on PGE(2)-matured DCs is ass...

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Bibliografske podrobnosti
Main Authors: Muthuswamy, Ravikumar, Mueller-Berghaus, Jan, Haberkorn, Uwe, Reinhart, Todd A., Schadendorf, Dirk, Kalinski, Pawel
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938836/
https://ncbi.nlm.nih.gov/pubmed/20498301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-12-258038
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