Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species

Unraveling the gene regulatory networks that govern development and function of the mammalian heart is critical for the rational design of therapeutic interventions in human heart disease. Using the Drosophila heart as a platform for identifying novel gene interactions leading to heart disease, we f...

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Hlavní autoři: Qian, Li, Wythe, Joshua D., Liu, Jiandong, Cartry, Jerome, Vogler, Georg, Mohapatra, Bhagyalaxmi, Otway, Robyn T., Huang, Yu, King, Isabelle N., Maillet, Marjorie, Zheng, Yi, Crawley, Timothy, Taghli-Lamallem, Ouarda, Semsarian, Christopher, Dunwoodie, Sally, Winlaw, David, Harvey, Richard P., Fatkin, Diane, Towbin, Jeffrey A., Molkentin, Jeffery D., Srivastava, Deepak, Ocorr, Karen, Bruneau, Benoit G., Bodmer, Rolf
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2011
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216339/
https://ncbi.nlm.nih.gov/pubmed/21690310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201006114
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