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Opera: Reconstructing Optimal Genomic Scaffolds with High-Throughput Paired-End Sequences

Scaffolding, the problem of ordering and orienting contigs, typically using paired-end reads, is a crucial step in the assembly of high-quality draft genomes. Even as sequencing technologies and mate-pair protocols have improved significantly, scaffolding programs still rely on heuristics, with no g...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Gao, Song, Sung, Wing-Kin, Nagarajan, Niranjan
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216105/
https://ncbi.nlm.nih.gov/pubmed/21929371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cmb.2011.0170
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