Intracellular neutralization of viral infection in polarized epithelial cells by neonatal Fc receptor (FcRn)-mediated IgG transport

IgG was traditionally thought to neutralize virions by blocking their attachment to or penetration into mucosal epithelial cells, a common site of exposure to viruses. However, we describe an intracellular neutralizing action for an influenza hemagglutinin-specific monoclonal antibody, Y8-10C2 (Y8),...

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Huvudupphovsmän: Bai, Yu, Ye, Lilin, Tesar, Devin B., Song, Haichen, Zhao, Deming, Björkman, Pamela J., Roopenian, Derry C., Zhu, Xiaoping
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215070/
https://ncbi.nlm.nih.gov/pubmed/22042859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115348108
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