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Noninvasive MRI of β-cell function using a Zn(2+)-responsive contrast agent
Elevation of postprandial glucose stimulates release of insulin from granules stored in pancreatic islet β-cells. We demonstrate here that divalent zinc ions coreleased with insulin from β-cells in response to high glucose are readily detected by MRI using the Zn(2+)-responsive T(1) agent, GdDOTA-di...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3215051/ https://ncbi.nlm.nih.gov/pubmed/22025712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109649108 |
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