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Noninvasive MRI of β-cell function using a Zn(2+)-responsive contrast agent

Elevation of postprandial glucose stimulates release of insulin from granules stored in pancreatic islet β-cells. We demonstrate here that divalent zinc ions coreleased with insulin from β-cells in response to high glucose are readily detected by MRI using the Zn(2+)-responsive T(1) agent, GdDOTA-di...

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Bibliografski detalji
Glavni autori: Lubag, Angelo J. M., De Leon-Rodriguez, Luis M., Burgess, Shawn C., Sherry, A. Dean
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215051/
https://ncbi.nlm.nih.gov/pubmed/22025712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109649108
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