Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation

Stimulation of resting CD4(+) T lymphocytes leads to rapid proliferation and differentiation into effector (Teff) or inducible regulatory (Treg) subsets with specific functions to promote or suppress immunity. Importantly, Teff and Treg use distinct metabolic programs to support subset specification...

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Autores principales: Michalek, Ryan D., Gerriets, Valerie A., Nichols, Amanda G., Inoue, Makoto, Kazmin, Dmitri, Chang, Ching-Yi, Dwyer, Mary A., Nelson, Erik R., Pollizzi, Kristen N., Ilkayeva, Olga, Giguere, Vincent, Zuercher, William J., Powell, Jonathan D., Shinohara, Mari L., McDonnell, Donald P., Rathmell, Jeffrey C.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215012/
https://ncbi.nlm.nih.gov/pubmed/22042850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108856108
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