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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4(+) T Cell Subsets

Stimulated CD4(+) T lymphocytes can differentiate into effector T cell (Teff) or inducible regulatory T cell (Treg) subsets with specific immunological roles. We show that Teff and Treg require distinct metabolic programs to support these functions. Th1, Th2, and Th17 cells expressed high surface le...

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Bibliografische gegevens
Hoofdauteurs: Michalek, Ryan D., Gerriets, Valerie A., Jacobs, Sarah R., Macintyre, Andrew N., MacIver, Nancie J., Mason, Emily F., Sullivan, Sarah A., Nichols, Amanda G., Rathmell, Jeffrey C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2011
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198034/
https://ncbi.nlm.nih.gov/pubmed/21317389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1003613
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