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Leptin Metabolically Licenses T Cells for Activation to Link Nutrition and Immunity

Immune responses are highly energy dependent processes. Activated T cells increase glucose uptake and aerobic glycolysis to survive and function. Malnutrition and starvation limit nutrients and are associated with immune deficiency and increased susceptibility to infection. While it is clear that im...

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Detalhes bibliográficos
Main Authors: Saucillo, Donte C., Gerriets, Valerie A., Sheng, John, Rathmell, Jeffrey C., MacIver, Nancie J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3872216/
https://ncbi.nlm.nih.gov/pubmed/24273001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1301158
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