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Bidirectional resection of DNA double-strand breaks by Mre11 and Exo1
Repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) requires resection of 5′-termini to generate 3′-single-strand DNA tails(1). Key components of this reaction are Exonuclease 1 and the bifunctional endo/exonuclease, Mre11(2-4). Mre11 endonuclease activity is critical when DSB...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3214165/ https://ncbi.nlm.nih.gov/pubmed/22002605 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10515 |
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