Anti-Transforming Growth Factor ß Antibody Treatment Rescues Bone Loss and Prevents Breast Cancer Metastasis to Bone

Breast cancer often metastasizes to bone causing osteolytic bone resorption which releases active TGFβ. Because TGFβ favors progression of breast cancer metastasis to bone, we hypothesized that treatment using anti-TGFβ antibody may reduce tumor burden and rescue tumor-associated bone loss in metast...

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Detalhes bibliográficos
Main Authors: Biswas, Swati, Nyman, Jeffry S., Alvarez, JoAnn, Chakrabarti, Anwesa, Ayres, Austin, Sterling, Julie, Edwards, James, Rana, Tapasi, Johnson, Rachelle, Perrien, Daniel S., Lonning, Scott, Shyr, Yu, Matrisian, Lynn M., Mundy, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214031/
https://ncbi.nlm.nih.gov/pubmed/22096521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027090
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