Multiple Modifications Allow High-Titer Production of Retroviral Vectors Carrying Heterologous Regulatory Elements

Tumor-specific expression of therapeutic genes is a prerequisite in many approaches to retrovirus-mediated cancer gene therapy. However, tissue specificity is often associated with a reduction in viral titer. To overcome this problem, we constructed a series of murine leukemia virus (MLV)-based retr...

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Autors principals: Hlavaty, Juraj, Stracke, Anika, Klein, Dieter, Salmons, Brian, Günzburg, Walter H., Renner, Matthias
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Gene Therapy
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC321378/
https://ncbi.nlm.nih.gov/pubmed/14722293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1384-1392.2004
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