Influence of vector design and host cell on the mechanism of recombination and emergence of mutant subpopulations of replicating retroviral vectors

BACKGROUND: The recent advent of murine leukaemia virus (MLV)-based replication-competent retroviral (RCR) vector technology has provided exciting new tools for gene delivery, albeit the advances in vector efficiency which have been realized are also accompanied by a set of fresh challenges. The exp...

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Bibliographic Details
Main Authors: Paar, Matthias, Klein, Dieter, Salmons, Brian, Günzburg, Walter H, Renner, Matthias, Portsmouth, Daniel
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645402/
https://ncbi.nlm.nih.gov/pubmed/19203366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2199-10-8
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