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Effects of Viral Strain, Transgene Position, and Target Cell Type on Replication Kinetics, Genomic Stability, and Transgene Expression of Replication-Competent Murine Leukemia Virus-Based Vectors

The limited efficiency of in vivo gene transfer by replication-deficient retroviral vectors remains an obstacle to achieving effective gene therapy for solid tumors. One approach to circumvent this problem is the use of replication-competent retroviral vectors. However, the application of such vecto...

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Detalhes bibliográficos
Main Authors: Paar, Matthias, Schwab, Sonja, Rosenfellner, Doris, Salmons, Brian, Günzburg, Walter H., Renner, Matthias, Portsmouth, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1933297/
https://ncbi.nlm.nih.gov/pubmed/17442710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02470-06
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