Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional In Vitro and In Vivo

Gene directed-enzyme prodrug therapy (GDEPT) is an approach for sensitization of tumor cells to an enzymatically activated, otherwise nontoxic, prodrug. Cytochrome P450 2B1 (CYP2B1) metabolizes the prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) to produce the cytotoxic substances phosphoramide...

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Bibliografske podrobnosti
Main Authors: Klein, Reinhard, Ruttkowski, Bärbel, Schwab, Sonja, Peterbauer, Thomas, Salmons, Brian, Günzburg, Walter H., Hohenadl, Christine
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2008
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291507/
https://ncbi.nlm.nih.gov/pubmed/18414588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/683505
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