Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional In Vitro and In Vivo

Gene directed-enzyme prodrug therapy (GDEPT) is an approach for sensitization of tumor cells to an enzymatically activated, otherwise nontoxic, prodrug. Cytochrome P450 2B1 (CYP2B1) metabolizes the prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) to produce the cytotoxic substances phosphoramide...

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Autores principales: Klein, Reinhard, Ruttkowski, Bärbel, Schwab, Sonja, Peterbauer, Thomas, Salmons, Brian, Günzburg, Walter H., Hohenadl, Christine
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2008
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291507/
https://ncbi.nlm.nih.gov/pubmed/18414588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/683505
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