Mouse Mammary Tumor Virus Promoter-Containing Retroviral Promoter Conversion Vectors for Gene-Directed Enzyme Prodrug Therapy are Functional In Vitro and In Vivo

Gene directed-enzyme prodrug therapy (GDEPT) is an approach for sensitization of tumor cells to an enzymatically activated, otherwise nontoxic, prodrug. Cytochrome P450 2B1 (CYP2B1) metabolizes the prodrugs cyclophosphamide (CPA) and ifosfamide (IFA) to produce the cytotoxic substances phosphoramide...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Klein, Reinhard, Ruttkowski, Bärbel, Schwab, Sonja, Peterbauer, Thomas, Salmons, Brian, Günzburg, Walter H., Hohenadl, Christine
Formato: Artigo
Idioma:Inglês
Publicado: Hindawi Publishing Corporation 2008
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2291507/
https://ncbi.nlm.nih.gov/pubmed/18414588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2008/683505
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares