Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1

Abdominal aortic aneurysm (AAA) is a common cause of morbidity and mortality and has a significant heritability. We carried out a genome-wide association discovery study of 1866 patients with AAA and 5435 controls and replication of promising signals (lead SNP with a p value < 1 × 10(−5)) in 2871...

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Main Authors: Bown, Matthew J., Jones, Gregory T., Harrison, Seamus C., Wright, Benjamin J., Bumpstead, Suzannah, Baas, Annette F., Gretarsdottir, Solveig, Badger, Stephen A., Bradley, Declan T., Burnand, Kevin, Child, Anne H., Clough, Rachel E., Cockerill, Gillian, Hafez, Hany, Scott, D. Julian A., Futers, Simon, Johnson, Anne, Sohrabi, Soroush, Smith, Alberto, Thompson, Matthew M., van Bockxmeer, Frank M., Waltham, Matthew, Matthiasson, Stefan E., Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Blankensteijn, Jan D., Teijink, Joep A.W., Wijmenga, Cisca, de Graaf, Jacqueline, Kiemeney, Lambertus A., Assimes, Themistocles L., McPherson, Ruth, Folkersen, Lasse, Franco-Cereceda, Anders, Palmen, Jutta, Smith, Andrew J., Sylvius, Nicolas, Wild, John B., Refstrup, Mette, Edkins, Sarah, Gwilliam, Rhian, Hunt, Sarah E., Potter, Simon, Lindholt, Jes S., Frikke-Schmidt, Ruth, Tybjærg-Hansen, Anne, Hughes, Anne E., Golledge, Jonathan, Norman, Paul E., van Rij, Andre, Powell, Janet T., Eriksson, Per, Stefansson, Kari, Thompson, John R., Humphries, Steve E., Sayers, Robert D., Deloukas, Panos, Samani, Nilesh J.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213391/
https://ncbi.nlm.nih.gov/pubmed/22055160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.10.002
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