Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-Like Factor 5 Expression by Ultrahigh-Throughput Screening

The transcription factor Krüppel-like factor 5 (KLF5) is primarily expressed in the proliferative zone of the mammalian intestinal epithelium where it regulates cell proliferation. Studies showed that inhibition of KLF5 expression reduces proliferation rates in human colorectal cancer cells and inte...

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Detalhes bibliográficos
Main Authors: Bialkowska, Agnieszka B., Crisp, Melissa, Bannister, Thomas, He, Yuanjun, Chowdhury, Sarwat, Schürer, Stephan, Chase, Peter, Spicer, Timothy, Madoux, Franck, Tian, Chenlu, Hodder, Peter, Zaharevitz, Daniel, Yang, Vincent W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213326/
https://ncbi.nlm.nih.gov/pubmed/21885866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0550
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