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CROSS-LINKING OF THE HUMAN DNA REPAIR PROTEIN O(6)-ALKYLGUANINE DNA ALKYLTRANSFERASE TO DNA IN THE PRESENCE OF 1,2,3,4-DIEPOXYBUTANE
1,2,3,4-Diepoxybutane (DEB) is a key carcinogenic metabolite of the important industrial chemical 1,3-butadiene. DEB is a bifunctional alkylating agent capable of reacting with DNA and proteins. Initial DNA alkylation by DEB produces N7-(2′-hydroxy-3′,4′-epoxybut-1′-yl)-guanine monoadducts, which ca...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3213031/ https://ncbi.nlm.nih.gov/pubmed/16696566 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx0600088 |
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