Cross-Linking of the DNA Repair Protein O(6)-Alkylguanine DNA Alkyltransferase to DNA in the Presence of Cisplatin

1,1,2,2- Cis-diamminedichloroplatinum (II) (cisplatin) is a chemotherapeutic agent widely used in the clinic to treat various cancers. The antitumor activity of cisplatin is generally attributed to its ability to form intrastrand and interstrand DNA-DNA cross-links via sequential platination of two...

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Bibliographic Details
Published in:DNA Repair (Amst)
Main Authors: Ming, Xun, Michaelson-Richie, Erin D., Groehler, Arnold S., Villalta, Peter W., Campbell, Colin, Tretyakova, Natalia Y.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8177102/
https://ncbi.nlm.nih.gov/pubmed/32283495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102840
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