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Cross-linking of the DNA repair protein O(6)-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

The antitumor activity of chemotherapeutic nitrogen mustards including chlorambucil, cyclophosphamide, and melphalan, is commonly attributed to their ability to induce DNA-DNA cross-links by consecutive alkylation of two nucleophilic sites within the DNA duplex. DNA-protein cross-linking by nitrogen...

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Detalhes bibliográficos
Main Authors: Loeber, Rachel, Michaelson, Erin, Fang, Qingming, Campbell, Colin, Pegg, Anthony, Tretyakova, Natalia
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825382/
https://ncbi.nlm.nih.gov/pubmed/18324787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7004508
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