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Cross-linking of the DNA repair protein O(6)-alkylguanine DNA alkyltransferase to DNA in the presence of antitumor nitrogen mustards

The antitumor activity of chemotherapeutic nitrogen mustards including chlorambucil, cyclophosphamide, and melphalan, is commonly attributed to their ability to induce DNA-DNA cross-links by consecutive alkylation of two nucleophilic sites within the DNA duplex. DNA-protein cross-linking by nitrogen...

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Autori principali: Loeber, Rachel, Michaelson, Erin, Fang, Qingming, Campbell, Colin, Pegg, Anthony, Tretyakova, Natalia
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825382/
https://ncbi.nlm.nih.gov/pubmed/18324787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx7004508
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