Overlap and effective size of the human CD8(+) T-cell receptor repertoire

Diversity in T-lymphocyte antigen receptors is generated by somatic rearrangement of T-cell receptor (TCR) genes and is concentrated within the third complementarity-determining region (CDR3) of each chain of the TCR heterodimer. We sequenced the CDR3 regions from millions of rearranged TCR β chain...

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Main Authors: Robins, Harlan S., Srivastava, Santosh K., Campregher, Paulo V., Turtle, Cameron J., Andriesen, Jessica, Riddell, Stanley R., Carlson, Christopher S., Warren, Edus H.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212437/
https://ncbi.nlm.nih.gov/pubmed/20811043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3001442
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