The Epigenetic Modifier PRDM5 Functions as a Tumor Suppressor through Modulating WNT/β-Catenin Signaling and Is Frequently Silenced in Multiple Tumors

BACKGROUND: PRDM (PRDI-BF1 and RIZ domain containing) proteins are zinc finger proteins involved in multiple cellular regulations by acting as epigenetic modifiers. We studied a recently identified PRDM member PRDM5 for its epigenetic abnormality and tumor suppressive functions in multiple tumorigen...

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Detalhes bibliográficos
Main Authors: Shu, Xing-sheng, Geng, Hua, Li, Lili, Ying, Jianming, Ma, Chunhong, Wang, Yajun, Poon, Fan Fong, Wang, Xian, Ying, Ying, Yeo, Winnie, Srivastava, Gopesh, Tsao, Sai Wah, Yu, Jun, Sung, Joseph J. Y., Huang, Shi, Chan, Anthony T. C., Tao, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210799/
https://ncbi.nlm.nih.gov/pubmed/22087297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027346
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