The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation

Interferon (IFN) regulatory factor 8 is encoded by a novel candidate tumor suppressor gene (IRF8), its promotor is frequently methylated in multiple cancers. However, the promoter methylation status, functions and underlying mechanisms of IRF8 in breast cancer remain unclear. We found that IRF8 was...

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Pubblicato in:Oncotarget
Autori principali: Luo, Xinrong, Xiong, Xin, Shao, Qing, Xiang, Tingxiu, Li, Lili, Yin, Xuedong, Li, Xia, Tao, Qian, Ren, Guosheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2017
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564732/
https://ncbi.nlm.nih.gov/pubmed/28388578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16511
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