The tumor suppressor interferon regulatory factor 8 inhibits β-catenin signaling in breast cancers, but is frequently silenced by promoter methylation

Interferon (IFN) regulatory factor 8 is encoded by a novel candidate tumor suppressor gene (IRF8), its promotor is frequently methylated in multiple cancers. However, the promoter methylation status, functions and underlying mechanisms of IRF8 in breast cancer remain unclear. We found that IRF8 was...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Luo, Xinrong, Xiong, Xin, Shao, Qing, Xiang, Tingxiu, Li, Lili, Yin, Xuedong, Li, Xia, Tao, Qian, Ren, Guosheng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5564732/
https://ncbi.nlm.nih.gov/pubmed/28388578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16511
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