Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produce Variants with Reduced Susceptibility to Antivirals

Hepatitis C virus (HCV) exhibits a high level of genetic variability, and variants with reduced susceptibility to antivirals can occur even before treatment begins. In addition, alcohol decreases efficacy of antiviral therapy and increases sequence heterogeneity of HCV RNA but how ethanol affects HC...

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Detalhes bibliográficos
Main Authors: Seronello, Scott, Montanez, Jessica, Presleigh, Kristen, Barlow, Miriam, Park, Seung Bum, Choi, Jinah
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210796/
https://ncbi.nlm.nih.gov/pubmed/22087316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027436
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