BASAL REACTIVE OXYGEN SPECIES DETERMINE THE SUSCEPTIBILITY TO APOPTOSIS IN CIRRHOTIC HEPATOCYTES

Hepatocytes from cirrhotic murine livers exhibit increased basal ROS activity and resistance to TGFβ-induced apoptosis, yet when ROS levels are decreased by antioxidant pretreatment, these cells recover susceptibility to apoptotic stimuli. To further study these redox events, hepatocytes from cirrho...

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Autores principales: Raval, Jay, Lyman, Suzanne, Nitta, Takashi, Mohuczy, Dagmara, Lemasters, John J., Kim, Jae-Sung, Behrns, Kevin E.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2006
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1773006/
https://ncbi.nlm.nih.gov/pubmed/17145552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2006.07.02
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