TRANSFORMING GROWTH FACTOR BETA MEDIATES HEPATOCYTE APOPTOSIS THROUGH SMAD3 GENERATION OF REACTIVE OXYGEN SPECIES

TGFβ induces hepatocyte apoptosis via reactive oxygen species (ROS) generation, the mitochondrial permeability transition (MPT), and caspase activation. The role of the Smad pathway in these events is unknown. In this study primary hepatocytes were isolated from Smad3 wild-type (+/+) and knockout (−...

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Detalhes bibliográficos
Main Authors: Black, Dalliah, Lyman, Suzanne, Qian, Ting, Lemasters, John J., Rippe, Richard A., Nitta, Takashi, Kim, Jae-Sung, Behrns, Kevin E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151473/
https://ncbi.nlm.nih.gov/pubmed/17936489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2007.09.001
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