TRANSFORMING GROWTH FACTOR BETA MEDIATES HEPATOCYTE APOPTOSIS THROUGH SMAD3 GENERATION OF REACTIVE OXYGEN SPECIES

TGFβ induces hepatocyte apoptosis via reactive oxygen species (ROS) generation, the mitochondrial permeability transition (MPT), and caspase activation. The role of the Smad pathway in these events is unknown. In this study primary hepatocytes were isolated from Smad3 wild-type (+/+) and knockout (−...

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Bibliografiset tiedot
Päätekijät: Black, Dalliah, Lyman, Suzanne, Qian, Ting, Lemasters, John J., Rippe, Richard A., Nitta, Takashi, Kim, Jae-Sung, Behrns, Kevin E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151473/
https://ncbi.nlm.nih.gov/pubmed/17936489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2007.09.001
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