Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins

Amyloidoses are diseases characterized by abnormal protein folding and self-assembly, for which no cure is available. Inhibition or modulation of abnormal protein self-assembly therefore is an attractive strategy for prevention and treatment of amyloidoses. We examined Lys-specific molecular tweezer...

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Huvudupphovsmän: Sinha, Sharmistha, Lopes, Dahabada H. J., Du, Zhenming, Pang, Eric S., Shanmugam, Akila, Lomakin, Aleksey, Talbiersky, Peter, Tennstaedt, Annette, McDaniel, Kirsten, Bakshi, Reena, Kuo, Pei-Yi, Ehrmann, Michael, Benedek, George B., Loo, Joseph A., Klärner, Frank-Gerrit, Schrader, Thomas, Wang, Chunyu, Bitan, Gal
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210512/
https://ncbi.nlm.nih.gov/pubmed/21916458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja206279b
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