Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study)

Multipotent mesenchymal stromal cells (MSCs) increase tissue plasminogen activator (tPA) activity in astrocytes of the ischemic boundary zone, leading to increased neurite outgrowth in the brain. To probe the mechanisms that underlie MSC-mediated activation of tPA, we investigated the morphogenetic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Xin, Hongqi, Li, Yi, Shen, Li Hong, Liu, Xianshuang, Hozeska-Solgot, Ann, Zhang, Rui Lan, Zhang, Zheng Gang, Chopp, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2011
Pynciau:
Original Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210339/
https://ncbi.nlm.nih.gov/pubmed/21829213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.116
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