Tissue Plasminogen Activator and Plasminogen Activator Inhibitor 1 Contribute to Sonic Hedgehog-Induced In Vitro Cerebral Angiogenesis

The molecular mechanisms underlying cerebral angiogenesis have not been fully investigated. Using primary mouse brain endothelial cells (MBECs) and a capillary-like tube formation assay, we investigated whether the sonic hedgehog (Shh) signaling pathway is coupled with the plasminogen/plasmin system...

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Bibliographic Details
Main Authors: Teng, Hua, Chopp, Michael, Hozeska-Solgot, Ann, Shen, Lihong, Lu, Mei, Tang, Clark, Zhang, Zheng Gang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3303815/
https://ncbi.nlm.nih.gov/pubmed/22432023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033444
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