Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study)

Multipotent mesenchymal stromal cells (MSCs) increase tissue plasminogen activator (tPA) activity in astrocytes of the ischemic boundary zone, leading to increased neurite outgrowth in the brain. To probe the mechanisms that underlie MSC-mediated activation of tPA, we investigated the morphogenetic...

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Detalhes bibliográficos
Main Authors: Xin, Hongqi, Li, Yi, Shen, Li Hong, Liu, Xianshuang, Hozeska-Solgot, Ann, Zhang, Rui Lan, Zhang, Zheng Gang, Chopp, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210339/
https://ncbi.nlm.nih.gov/pubmed/21829213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.116
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