Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging

The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades...

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Autori principali: Maarouf, Chera L., Daugs, Ian D., Kokjohn, Tyler A., Walker, Douglas G., Hunter, Jesse M., Kruchowsky, Jane C., Woltjer, Randy, Kaye, Jeffrey, Castaño, Eduardo M., Sabbagh, Marwan N., Beach, Thomas G., Roher, Alex E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210154/
https://ncbi.nlm.nih.gov/pubmed/22087282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027291
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