Alzheimer's Disease and Non-Demented High Pathology Control Nonagenarians: Comparing and Contrasting the Biochemistry of Cognitively Successful Aging

The amyloid cascade hypothesis provides an economical mechanistic explanation for Alzheimer's disease (AD) dementia and correlated neuropathology. However, some nonagenarian individuals (high pathology controls, HPC) remain cognitively intact while enduring high amyloid plaque loads for decades...

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Hlavní autoři: Maarouf, Chera L., Daugs, Ian D., Kokjohn, Tyler A., Walker, Douglas G., Hunter, Jesse M., Kruchowsky, Jane C., Woltjer, Randy, Kaye, Jeffrey, Castaño, Eduardo M., Sabbagh, Marwan N., Beach, Thomas G., Roher, Alex E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210154/
https://ncbi.nlm.nih.gov/pubmed/22087282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027291
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