Concurrent HDAC and mTORC1 Inhibition Attenuate Androgen Receptor and Hypoxia Signaling Associated with Alterations in MicroRNA Expression

Specific inhibitors towards Histone Deacetylases (HDACs) and Mammalian Target of Rapamycin Complex 1 (mTORC1) have been developed and demonstrate potential as treatments for patients with advanced and/or metastatic and castrate resistant prostate cancer (PCa). Further, deregulation of HDAC expressio...

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Autori principali: Ellis, Leigh, Lehet, Kristin, Ramakrishnan, Swathi, Adelaiye, Remi, Miles, Kiersten M., Wang, Dan, Liu, Song, Atadja, Peter, Carducci, Michael A., Pili, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210144/
https://ncbi.nlm.nih.gov/pubmed/22087262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027178
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