Bile Acid Sequestration Reduces Plasma Glucose Levels in db/db Mice by Increasing Its Metabolic Clearance Rate

AIMS/HYPOTHESIS: Bile acid sequestrants (BAS) reduce plasma glucose levels in type II diabetics and in murine models of diabetes but the mechanism herein is unknown. We hypothesized that sequestrant-induced changes in hepatic glucose metabolism would underlie reduced plasma glucose levels. Therefore...

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Main Authors: Meissner, Maxi, Herrema, Hilde, van Dijk, Theo H., Gerding, Albert, Havinga, Rick, Boer, Theo, Müller, Michael, Reijngoud, Dirk-Jan., Groen, Albert K., Kuipers, Folkert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210115/
https://ncbi.nlm.nih.gov/pubmed/22087215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0024564
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