Specific knockdown of uPA/uPAR attenuates invasion in glioblastoma cells and xenografts by inhibition of cleavage and trafficking of Notch -1 receptor

BACKGROUND: uPA/uPAR is a multifunctional system that is over expressed in many cancers and plays a critical role in glioblastoma (GBM) invasion. Previous studies from our lab have also shown that uPA/uPAR down regulation inhibits cancer cell invasion in SNB 19 GBM cells. METHODS: As Notch 1 is know...

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Hlavní autoři: Raghu, Hari, Gondi, Christopher S, Dinh, Dzung H, Gujrati, Meena, Rao, Jasti S
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210098/
https://ncbi.nlm.nih.gov/pubmed/22004682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-10-130
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