uPA and uPAR shRNA inhibit angiogenesis via enhanced secretion of SVEGFR1 independent of GM‐CSF but dependent on TIMP‐1 in endothelial and glioblastoma cells

The uPA/uPAR system is known to play a critical role in angiogenesis of glioblastoma. Previously, we have shown that shRNA against uPA and uPAR attenuates angiogenesis by blocking nuclear translocation of angiogenin, inhibition of angiopoietin/Tie2 signaling, and regulating several other pro‐angioge...

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Detalhes bibliográficos
Main Authors: Raghu, Hari, Nalla, Arun Kumar, Gondi, Christopher S., Gujrati, Meena, Dinh, Dzunh H., Rao, Jasti S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2011
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3268919/
https://ncbi.nlm.nih.gov/pubmed/22177802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2011.11.008
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