PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine

BACKGROUND: Prostatic acid phosphatase (PAP) and ecto-5'-nucleotidase (NT5E, CD73) produce extracellular adenosine from the nucleotide AMP in spinal nociceptive (pain-sensing) circuits; however, it is currently unknown if these are the main ectonucleotidases that generate adenosine or how rapid...

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Autors principals: Street, Sarah E, Walsh, Paul L, Sowa, Nathaniel A, Taylor-Blake, Bonnie, Guillot, Thomas S, Vihko, Pirkko, Wightman, R Mark, Zylka, Mark J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210096/
https://ncbi.nlm.nih.gov/pubmed/22011440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-80
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