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Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning

Translation of Hepatitis C viral proteins requires an internal ribosome entry site (IRES) located in the 5′ untranslated region of the viral mRNA. The core domain of the Hepatitis C virus (HCV) IRES contains a four-way helical junction that is integrated within a predicted pseudoknot. This domain is...

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Bibliografiske detaljer
Main Authors: Berry, Katherine E., Waghray, Shruti, Mortimer, Stefanie A., Bai, Yun, Doudna, Jennifer A.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209822/
https://ncbi.nlm.nih.gov/pubmed/22000514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.08.002
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