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Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning

Translation of Hepatitis C viral proteins requires an internal ribosome entry site (IRES) located in the 5′ untranslated region of the viral mRNA. The core domain of the Hepatitis C virus (HCV) IRES contains a four-way helical junction that is integrated within a predicted pseudoknot. This domain is...

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Autors principals: Berry, Katherine E., Waghray, Shruti, Mortimer, Stefanie A., Bai, Yun, Doudna, Jennifer A.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209822/
https://ncbi.nlm.nih.gov/pubmed/22000514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2011.08.002
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