G-quadruplex-induced instability during leading-strand replication

G-quadruplexes are four-stranded nucleic acid structures whose biological functions remain poorly understood. In the yeast S. cerevisiae, we report that G-quadruplexes form and, if not properly processed, pose a specific challenge to replication. We show that the G-quadruplex-prone CEB1 tandem array...

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Autores principales: Lopes, Judith, Piazza, Aurèle, Bermejo, Rodrigo, Kriegsman, Barry, Colosio, Arianna, Teulade-Fichou, Marie-Paule, Foiani, Marco, Nicolas, Alain
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209785/
https://ncbi.nlm.nih.gov/pubmed/21873979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.316
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