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Mechanism of transcriptional repression at a bacterial promoter by analysis of single molecules

The molecular basis for regulation of lactose metabolism in Escherichia coli is well studied. Nonetheless, the physical mechanism by which the Lac repressor protein prevents transcription of the lactose promoter remains unresolved. Using multi-wavelength single-molecule fluorescence microscopy, we v...

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Bibliografski detalji
Glavni autori: Sanchez, Alvaro, Osborne, Melisa L, Friedman, Larry J, Kondev, Jane, Gelles, Jeff
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209775/
https://ncbi.nlm.nih.gov/pubmed/21829165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.273
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