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Decreases in Valosin-Containing Protein result in increased levels of tau phosphorylated at Ser(262/356)
VCP/p97 is a multifunctional AAA+-ATPase involved in vesicle fusion, proteasomal degradation, and autophagy. Reported dysfunctions of these processes in Alzheimer disease (AD), along with the linkage of VCP/p97 to inclusion body myopathy with Paget’s disease and frontotemporal dementia (IBMPFD) led...
Bewaard in:
| Hoofdauteurs: | , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2011
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3209510/ https://ncbi.nlm.nih.gov/pubmed/21983102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.09.032 |
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