Decreases in Valosin-Containing Protein result in increased levels of tau phosphorylated at Ser(262/356)

VCP/p97 is a multifunctional AAA+-ATPase involved in vesicle fusion, proteasomal degradation, and autophagy. Reported dysfunctions of these processes in Alzheimer disease (AD), along with the linkage of VCP/p97 to inclusion body myopathy with Paget’s disease and frontotemporal dementia (IBMPFD) led...

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Detalhes bibliográficos
Principais autores: Dolan, Philip J., Jin, Youngnam N., Hwang, Woong, Johnson, Gail V.W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209510/
https://ncbi.nlm.nih.gov/pubmed/21983102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.09.032
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