A Double-Inactivated Severe Acute Respiratory Syndrome Coronavirus Vaccine Provides Incomplete Protection in Mice and Induces Increased Eosinophilic Proinflammatory Pulmonary Response upon Challenge

Severe acute respiratory syndrome coronavirus (SARS-CoV) is an important emerging virus that is highly pathogenic in aged populations and is maintained with great diversity in zoonotic reservoirs. While a variety of vaccine platforms have shown efficacy in young-animal models and against homologous...

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Detalhes bibliográficos
Main Authors: Bolles, Meagan, Deming, Damon, Long, Kristin, Agnihothram, Sudhakar, Whitmore, Alan, Ferris, Martin, Funkhouser, William, Gralinski, Lisa, Totura, Allison, Heise, Mark, Baric, Ralph S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209347/
https://ncbi.nlm.nih.gov/pubmed/21937658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06048-11
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