Cargando...

Feedback Control of p53 Translation by REDD1 and mTORC1 Limits the p53-Dependent DNA Damage Response

Exquisite control of the level and activity of p53 are required in order to preserve cellular homeostasis following DNA damage. How this regulation is integrated with other key metabolic pathways in vivo is poorly understood. Here, we describe an endogenous feedback circuit for regulation of p53 thr...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Vadysirisack, Douangsone D., Baenke, Franziska, Ory, Benjamin, Lei, Kui, Ellisen, Leif W.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209328/
https://ncbi.nlm.nih.gov/pubmed/21896779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05541-11
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!