Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus

Covalently closed circular DNA (cccDNA), the nuclear form of hepatitis B virus (HBV), is synthesized by repair of the relaxed circular (RC) DNA genome. Initially, cccDNA is derived from RC DNA from the infecting virion, but additional copies of cccDNA are derived from newly synthesized RC DNA molecu...

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Bibliographic Details
Main Authors: Lentz, Thomas B., Loeb, Daniel D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209309/
https://ncbi.nlm.nih.gov/pubmed/21900164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05373-11
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