Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair

Each day, approximately 20,000 oxidative lesions form in the DNA of every nucleated human cell. The base excision repair (BER) enzymes that repair these lesions must function in a chromatin milieu. We have determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and DNA polymerase β (...

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Bibliografiske detaljer
Main Authors: Odell, Ian D., Barbour, Joy-El, Murphy, Drew L., Della-Maria, Julie A., Sweasy, Joann B., Tomkinson, Alan E., Wallace, Susan S., Pederson, David S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209256/
https://ncbi.nlm.nih.gov/pubmed/21930793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05715-11
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