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Nucleosome Disruption by DNA Ligase III-XRCC1 Promotes Efficient Base Excision Repair

Each day, approximately 20,000 oxidative lesions form in the DNA of every nucleated human cell. The base excision repair (BER) enzymes that repair these lesions must function in a chromatin milieu. We have determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and DNA polymerase β (...

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Detalhes bibliográficos
Main Authors: Odell, Ian D., Barbour, Joy-El, Murphy, Drew L., Della-Maria, Julie A., Sweasy, Joann B., Tomkinson, Alan E., Wallace, Susan S., Pederson, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209256/
https://ncbi.nlm.nih.gov/pubmed/21930793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.05715-11
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